OK, I *think* I have it figured out. I did this and so far things seem to work.

.htaccess (note the last bit, that needs to be changed to your URL if you use this code)
Code:
Options +FollowSymLinks
RewriteEngine on

RewriteRule ^admin$ - [L]
RewriteRule ^admin/(.*) - [L]
RewriteRule ^install$ - [L]
RewriteRule ^install/(.*) - [L]
RewriteRule ^$ index.php
RewriteRule ^view/(.*)/(.*)/ view_video.php?id=$1  [L,QSA]
RewriteRule ^tag/(.*)/(.*) tag.php?search_id=$1&page=$2  [L,QSA]
RewriteRule ^channel/(.*)/(.*)/recent/(.*) video.php?category=recent&chid=$1&page=$3
RewriteRule ^channel/(.*)/(.*)/viewed/(.*) video.php?category=viewed&chid=$1&page=$3
RewriteRule ^channel/(.*)/(.*)/ channel_detail.php?id=$1

RewriteRule ^detailed/recent/(.*) video.php?category=recent&page=$1&viewtype=detailed
RewriteRule ^detailed/viewed/(.*) video.php?category=viewed&page=$1&viewtype=detailed
RewriteRule ^detailed/discussed/(.*) video.php?category=discussed&page=$1&viewtype=detailed
RewriteRule ^detailed/favorites/(.*) video.php?category=favorites&page=$1&viewtype=detailed
RewriteRule ^detailed/rated/(.*) video.php?category=rated&page=$1&viewtype=detailed
RewriteRule ^detailed/featured/(.*) video.php?category=featured&page=$1&viewtype=detailed
RewriteRule ^detailed/random/(.*) video.php?category=random&page=$1&viewtype=detailed
RewriteRule ^recent/(.*) video.php?category=recent&page=$1
RewriteRule ^viewed/(.*) video.php?category=viewed&page=$1
RewriteRule ^discussed/(.*) video.php?category=discussed&page=$1
RewriteRule ^favorites/(.*) video.php?category=favorites&page=$1
RewriteRule ^rated/(.*) video.php?category=rated&page=$1
RewriteRule ^featured/(.*) video.php?category=featured&page=$1
RewriteRule ^random/(.*) video.php?category=random&page=$1
RewriteRule ^rss/new/ rss.php?type=new [L]
RewriteRule ^rss/comments/ rss.php?type=comments [L]
RewriteRule ^rss/views/ rss.php?type=views [L]
RewriteRule ^group/(.*)/members/(.*) group_members.php?urlkey=$1&page=$2
RewriteRule ^group/(.*)/videos/(.*) group_videos.php?urlkey=$1&page=$2
RewriteRule ^group/(.*)/add/(.*) add_video.php?urlkey=$1&page=$2
RewriteRule ^group/(.*)/fav/(.*) add_favour.php?urlkey=$1&page=$2
RewriteRule ^group/(.*)/topic/(.*) group_posts.php?urlkey=$1&tid=$2
RewriteRule ^group/(.*)/invite/ invite_members.php?urlkey=$1 [L,QSA]
RewriteRule ^group/(.*)/ groups_home.php?urlkey=$1  [L,QSA]
RewriteRule ^groups/(.*)/(.*)/(.*) groups.php?chid=$1&page=$3
RewriteRule ^groups/(.*)/(.*) groups.php?category=$1&page=$2
RewriteRule ^include/(.*) http://www.vshare.in
RewriteRule ^pages/(.*).html$ show_page.php?name=$1 [QSA,L]
RewriteRule ^([^/\.]+)/favorites/(.*) user_favorites.php?username=$1&page=$2
RewriteRule ^([^/\.]+)/playlist/(.*) playlist.php?username=$1&page=$2
RewriteRule ^([^/\.]+)/friends/(.*) user_friends.php?username=$1&page=$2
RewriteRule ^([^/\.]+)/public/(.*)$ user_videos.php?username=$1&type=public&page=$2
RewriteRule ^([^/\.]+)/private/(.*)$ user_videos.php?username=$1&type=private&page=$2 [L,QSA]
RewriteRule ^([^/\.]+)/groups/(.*)$ user_groups.php?username=$1&page=$2 [L,QSA]
RewriteRule ^([^/\.]+)?/?$ user.php?username=$1 [L,QSA]

<IfModule mod_security.c>
SecFilterEngine Off
SecFilterScanPOST Off
</IfModule>

<IfModule mod_gzip.c>
mod_gzip_on No
</IfModule>

RewriteEngine on
RewriteCond %{HTTP_REFERER} !^$
RewriteCond %{HTTP_REFERER} !^http://(www\.)?YOURDOMAIN.COM(/)?.*$ [NC]
RewriteRule \.(flv|swf|png|bmp|js|css|jpg|jpe?g|gif)$ templates/images/logo.jpg [L,NC]
php.ini
Code:
upload_max_filesize = 100M 
post_max_size = 100M 
output_buffering = on 
max_execution_time = 1000 
max_input_time = 1000 
session.gc_maxlifetime = 14400 

max_execution_time = 6000000
max_input_time = 600000
output_buffering = On